Carbohydrate-Aminoacid Linked Compounds.

Synthesis of rigid p-terphenyl-linked carbohydrate mimetics

An approach to β-D-2-aminotalose- and β-D-2-aminoidose-configured carbohydrate mimetics bearing a phenyl substituent is described. Unnatural divalent rigid p-terphenyl-linked C-aryl glycosides with 2.0 nm dimension are available using Suzuki cross-couplings. The key compound, a p-bromophenyl-substituted 1,2-oxazine, was prepared by a stereoselective [3 + 3]-cyclization of a D-isoascorbic acid-d...

Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate

As HIV-1-encoded envelope protein traverses the secretory pathway, it may be modified with N- and O-linked carbohydrate. When the gp120s of HIV-1 NL4-3, HIV-1 YU2, HIV-1 Bal, HIV-1 JRFL, and HIV-1 JRCSF were expressed as secreted proteins, the threonine at consensus position 499 was found to be O-glycosylated. For SIVmac239, the corresponding threonine was also glycosylated when gp120 was recom...

Brazil Nut Powdered Milk: Aminoacid Profile

Appreciated for its exotic flavor and considered a nutrient-rich food, Brazil nut is composed mostly of unsaturated fatty acids and high biological value proteins. The aim of this study was to evaluate the profile of amino acids in Brazil nut powdered milk using an HPLC system. The Brazil nut powdered milk was featured and the aminoacid profile was evaluated. The amino acids values of glutamic ...

Expeditious syntheses of two carbohydrate-linked cisplatin analogs.

The syntheses of two carbohydrate-linked cisplatin analogs, namely lacto- and alpha-Gal-cisplatin, are described. A fusion enzymatic approach was used to create the diazido-alpha-Gal trisaccharide intermediate in the synthesis of alpha-Gal-cisplatin.

Insulin, Glucagon, C-Peptide and Aminoacid Levels Following Liver Transplantation